How to handle stress as a Transperson ?

What are the effects of stress from living in a closet?

So one is that you are not happy living the life that you do not think is the correct life. You are a trans person and to constantly act like a cis person can get tiring. So dysphoria means mild sadness so it can develop into severe depression. It is much worse if you give in to family pressure and get married. That makes things much worse. This happens with both gender  identity as well as sexual orientation where people get married because they cannot deny their parents and they do all of this because they are being supported by their parents. Then all of this makes a bigger mess. So living in the closet is extremely stressful and unless you successfully transfer it into something else till then  it will keep nagging you. 

Does it manifest into physical health issues?

Normally stress can cause hypertension and other maladies but not stress because of living in the closet. There is no study that says that living in the closet increases your risk of the disease. It is only the psychological consequences.