Mr_fbits lemmi be honest....effects or affects would be individual. For my case, I have been taking diane since my hrt started, and luckily everything is good so far. But many people do face issues with diane, like liver kidney malfunction, blood clots, etc. So, take it for 3-4 months, get ur LFT KFT and lipid profiles tested...and if everything seems good, diane is working for u.